These data on the geography and scale of spillover can be used to target surveillance and prevention programs for potential future bat-CoV emergence.Įmerging coronaviruses (CoVs) of wildlife origin have significantly disrupted global health security and economies during the last two decades 1, 2. We then use probabilistic risk assessment and data on human-bat contact, human viral seroprevalence, and antibody duration to estimate that a median of 66,280 people (95% CI: 65,351–67,131) are infected with SARSr-CoVs annually in Southeast Asia. We derive current range distributions for known bat SARSr-CoV hosts and quantify their overlap with human populations. Each zoonotic spillover of a novel virus represents an opportunity for evolutionary adaptation and further spread therefore, quantifying the extent of this spillover may help target prevention programs. Evidence suggests that some bat SARS-related coronaviruses (SARSr-CoVs) could infect people directly, and that their spillover is more frequent than previously recognized. Emerging diseases caused by coronaviruses of likely bat origin (e.g., SARS, MERS, SADS, COVID-19) have disrupted global health and economies for two decades.
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